USPTO Patents Application 10766566

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.EXAMDRIA, VA 22313-1450

^Sfine C. Stracker

PATENT

Attorney's Docket No.: 00026.05CON

IN THE UNITED STATES PATENT AND TRADEMARK OFFICE

Applicant: Rabinowitz et al.
Serial No.: 10/766,566
Filed: 1/27/2004

Title DELIVERY OF ANTIDEPRESSANTS THROUGH AN INHALATION

ROUTE

Mail Stop Amendment
Commissioner for Patents
P.O. Box 1450
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INFORMATION DISCLOSURE STATEMENT

Dear Sir:

In accordance with their continuing duty of disclosure under 37 CFR §§ §1.97,
1.98 and 1.56, Applicants hereby submit for consideration in the above-identified
application the enclosed references. The Information Disclosure statement submitted
herewith is being filed within three months of the filing of a national application other
than a continued prosecution application under 37 CFR 1.53(d); within three months of
the date of entry of the national stage as set forth in 37 CFR 1 .491 in an international
application; before the mailing of a first Office Action on the merits, or before the
mailing of a first Office Action after the filing of a request for continued examination
under 37 CFR 1.114.

For the convenience of the Examiner, the references are listed on a PTO Form
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Examiner initialing and returning the Form PTO- 1449, indicating that the information has
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direct all correspondence to the following customer number.

Respectfully submitted,
8£P. 2 4 2004

Date: ,

. ~jLS

aine C. Stracker J.D., Ph.D., Reg. 43*166

Alexza Molecular Delivery Corporation
1001 East Meadow Circle
Palo Alto, CA 94303
TEL: (650)687-3905
FAX: (650)687-3999

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Art Unit

Examiner Name

Attorney Docket Number

10/766,566

1/27/2004

Joshua D. Rabinowitz

Not yet known

To be assigned

00026.05CON

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ALEXZA MDC, 1001 East Meadow Circle, Palo Alto, CA 9430J
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Customer Number 37485

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If you need assistance in completing the form, call 1-800-PTO-9199 and select option 2.

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PTO/SB/08 (2-92)
Sheet 1 of 8

FonifcPTO-1449 M

INFORMATION DISCLOSURE CITATION
IN AN APPLICATION

(Use several sheets if necessary)

Docket Number: 00026.05CON

Application Number: 10/766,566

Applicant: Joshua D. RABINOWITZ et al.

Filing Date: 1/27/2004

Group Art Unit: Not Yet Known

U.S. PATENT DOCUMENTS

Examiner
initials

Ref.

INO.

Date

Document No.

Name

Class

Subclass

Filing Date If

/A.upi upi lalC

1

1 .

no /no/1 Q71

UZ/UZ/ ljr7 1

j,DOU,OU /

TIT r\ f-f-1 a-\ j nf ol

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o
z.

p P i(\ OS^

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J.

m /o^/i oon

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A 71 O

H,oyjy / iy

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A

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u:// 1 // iyy i

IvdUIldKi 1M1I1 Ull

c
J.

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uj/uo/ iyy**

5 OQO AQQ

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D.

no /i a/1 oo^

UZ/ 14/1 y y D

^3528 ^7A

TfS rtflKfof n C oil

inge ore inscn

7

/.

Uo/i j/iyvo

^ SAA fiAfi

i-rioyu ex ai.

Q
O.

nfi/1 0/1 Q07

Uo/ 1 z/ 1 /

5 501

IlOuSOTl CL al.

Q

1 O/nQ/1 Q07

iz/uy/ iyy /

^ £QA Q1 Q

j,oy*+ 5 y iy

ivUDSallicn cl al.

in

nA/n7/i qos
u**/u // iyyo

^ 71< 061

IVUUoainCIl Cl al.

1 1
1 1 .

nA/1 A/1 QQft

u*f/ 1*1/ iyyo

^ 718 86^

UalCilWal cl dl.

i o

1Z.

n^/no/1 qqq
uo/uz/ iyyo

c 7<o «7

1VTT cl al.

13.

06/29/1999

5,915,378

Lloyd et al.

14.

08/10/1999

5,934,272

Lloyd et al.

15.

09/28/1999

5,957,124

Lloyd et al.

16.

10/05/1999

5,960,792

Lloyd et al.

17.

11/30/1999

5,993,805

Sutton et al.

18.

03/28/2000

6,041,777

Faithfull et al.

19.

04/18/2000

6,051,566

Bianco

20.

08/01/2000

6,095,153

Kessler et al.

21.

08/15/2000

6,102,036

Slutsky et al.

22.

10/31/2000

6,140,323

Ellinwood, Jr. et al.

23.

06/05/2001

6,241,969

Saidi et al.

24.

07/03/2001

6,255,334

Sands

25.

10/23/2001

6,306,431

Zhang et al.

EXAMINER:

DATE CONSIDERED:

EXAMINER: Initial if citation considered, whether or not the citation conforms with MPEP 609. Draw a line through the citation if not in
conformance and not considered. Include a copy of this form with next communication to applicant.

PTO/SB/08 (2-92)

Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE

FormPTO-1449

INFORMATION DISCLOSURE CITATION
IN AN APPLICATION

(Use several sheets if necessary)

Docket Number: 00026.05CON

Application Number: 10/766,566

Applicant: Joshua D. RABLNOWITZ et al.

Filing Date: 1/27/2004

Group Art Unit: Not Yet Known

PTO/SB/08 (2-92)
Sheet 2 of 8

26.

07/16/2002

6,420,351

Tsai et al.

27.

01/14/2003

6,506,762

Horvath et al.

28.

02/04/2003

6,514,482

Bartus et al.

29.

07/15/2003

6,591,839

Meyer et al.

30.

09/06/2001

US 2001/0020147

Staniforth et al.

31.

03/28/2002

US 2002/0037828

Wilson et al.

32.

05/16/2002

US 2002/0058009

Bartus et al.

33.

07/04/2002

US 2002/0086852

Cantor

34.

08/22/2002

US 2002/0112723

Schuster et al.

35.

11/28/2002

US 2002/0176841

Barker et al.

36.

01/02/2003

US 2003/0004142

Prior et al.

RELATED ALEXZA MOLECULAR DELIVERY CORPORATION PATENT DOCUMENTS

37.

08/04/2003

10/633,876

Hale et al.

38.

08/04/2003

10/633,877

Hale et al.

39.

12/30/2003

10/749,537

Rabinowitz et al.

40.

12/30/2003

10/749,539

Rabinowitz et al.

41.

01/27/2004

10/766,149

Rabinowitz et al.

42.

01/27/2004

10/766,279

Rabinowitz et al.

43.

01/27/2004

10/766,574

Rabinowitz et al.

44.

01/27/2004

10/766,634

Rabinowitz et al.

45.

01/27/2004

10/766,647

Rabinowitz et al.

46.

01/28/2004

10/767,115

Rabinowitz et al.

47.

01/29/2004

10/768,205

Rabinowitz et al.

48.

01/29/2004

10/768,220

Rabinowitz et al.

49.

01/29/2004

10/768,281

Rabinowitz et al.

50.

01/29/2004

10/768,293

Rabinowitz et al.

51.

01/30/2004

10/769,046

Rabinowitz et al.

52.

01/30/2004

10/769,051

Rabinowitz et al.

EXAMINER:

DATE CONSIDERED:

EXAMINER: Initial if citation considered, whether or not the citation conforms with MPEP 609. Draw a line through the citation if not in
conformance and not considered. Include a copy of this form with next communication to applicant.

PTO/SB/ 08 (2-92)

Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE

PTO/SB/08 (2-92)
Sheet 3 of 8

FomiPTO-1449

INFORMATION DISCLOSURE CITATION
IN AN APPLICATION

(Use several sheets if necessary)

Docket Number: 00026.05CON

Application Number: 10/766,566

Applicant: Joshua D. RABINOWITZ et al.

Filing Date: 1/27/2004

Group Art Unit: Not Yet Known

53.

01/29/2004

10/769,157

Rabinowitz et al.

54.

01/29/2004

10/769,197

Rabinowitz et al.

55.

02/09/2004

10/775,583

Rabinowitz et al.

56.

02/09/2004

10/775,586

Rabinowitz et al.

57.

03/03/2004

10/791,915

Hale et al.

58.

03/03/2004

10/792,001

Rabinowitz et al.

59.

03/03/2004

10/792,012

Hale et al.

60.

03/03/2004

10/792,013

Rabinowitz et al.

61.

03/03/2004

10/792,096

Hale et al.

62.

03/03/2004

10/792,239

Hale et al.

63.

03/31/2004

10/813,721

Rabinowitz et al.

64.

03/31/2004

10/813,722

Rabinowitz et al.

65.

03/31/2004

10/814,690

Rabinowitz et al.

66.

03/31/2004

10/814,998

Rabinowitz et al.

67.

04/01/2004

10/815,527

Rabinowitz et al.

68.

04/01/2004

10/816,407

Rabinowitz et al.

69.

04/01/2004

10/816,492

Rabinowitz et al.

70.

04/01/2004

10/816,567

Rabinowitz et al.

71.

08/04/2004

10/912,462

Hale et al.

72.

01/23/2003

US 2003/0015196

Hodges et al.

73.

04/03/2003

US 2003/0062042

Wensiey et al.

74.

11/13/2003

US 2003/0209240

Hale et al.

75.

01/02/2003

US 2003/0000518

Rabinowitz et al.

76.

01/09/2003

US 2003/0005924

Rabinowitz et al.

77.

01/09/2003

US 2003/0005925

Hale et al.

78.

01/09/2003

US 2003/0007933

Rabinowitz et al.

79.

01/09/2003

US 2003/0007934

Rabinowitz et al.

80.

01/16/2003

US 2003/0012737

Rabinowitz et al.

81.

01/16/2003

US 2003/0012738

Rabinowitz et al.

82.

1/16/2003

US 2003/0012740

Rabinowitz et al.

EXAMINER:

DATE CONSIDERED:

EXAMINER: Initial if citation considered, whether or not the citation conforms with MPEP 609. Draw a line through the citation if not in
conformance and not considered. Include a copy of this form with next communication to applicant.

PTO/SB/ 08 (2-92) Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE

PTO/SB/08 (2-92)
Sheet 4 of 8

Form PTO-1449

INFORMATION DISCLOSURE CITATION
IN AN APPLICATION

(Use several sheets if necessary)

Docket Number: 00026.05CON

Application Number: 10/766,566

Applicant: Joshua D. RABINOWITZ et al.

Filing Date: 1/27/2004

Group Art Unit: Not Yet Known

83.

01/23/2003

US 2003/0015189

Rabinowitz et al.

84.

01/23/2003

US 2003/0015190

Rabinowitz et al.

85.

01/23/2003

US 2003/0017114

Rabinowitz et al.

86.

01/23/2003

US 2003/0017115

Rabinowitz et al.

87.

01/23/2003

US 2003/0017116

Rabinowitz et al.

88.

01/23/2003

US 2003/0017117

Rabinowitz et al.

89.

01/23/2003

US 2003/0017118

Rabinowitz et al.

90.

01/23/2003

US 2003/0017119

Rabinowitz et al.

91.

01/23/2003

US 2003/0017120

Rabinowitz et al.

92.

1/30/2003

US 2003/0021753

Rabinowitz et al.

93.

01/30/2003

US 2003/0021754

Rabinowitz et al.

94.

01/30/2003

US 2003/0021755

Hale et al.

95.

02/20/2003

US 2003/0035776

Hodges et al.

96.

05/15/2003

. US 2003/0091511

Rabinowitz et al.

97.

05/27/2004

US 2004/010148

Hale et al.

98.

07/31/2003

US 2003/0138382

Rabinowitz

99.

11/06/2003

US 2003/0206869

Rabinowitz et al.

100.

01/15/2004

US 2004/0009128

Rabinowitz et al.

101.

05/20/2004

US 2004/0096402

Hodges et al.

102.

05/27/2004

US 2004/0099269

Hale et al.

103.

06/03/2004

US 2004/0105818

Hale et al.

104.

06/03/2004

US 2004/0105819

Hale et al.

105.

07/01/2004

US 2004/0126326

Rabinowitz et al.

106.

07/01/2004

US 2004/0126327

Rabinowitz et al.

107.

07/01/2004

US 2004/0126328

Rabinowitz et al.

108.

07/01/2004

US 2004/0126329

Rabinowitz et al.

109.

07/01/2004

US 2004/0127481

Rabinowitz et al.

110.

07/01/2004

US 2004/0127490

Rabinowitz et al.

111.

08/12/2004

US 2004/0156788

Rabinowitz et al.

112.

08/12/2004

US 2004/0156789

Rabinowitz et al.

EXAMINER:

DATE CONSIDERED:

EXAMINER: Initial if citation considered, whether or not the citation conforms with MPEP 609. Draw a line through the citation if not in
conformance and not considered. Include a copy of this form with next communication to applicant.

PTO/SB/ 08 (2-92) Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE

PTO/SB/08 (2-92)
Sheet 5 of 8

FormPTO-1449

INFORMATION DISCLOSURE CITATION
IN AN APPLICATION

(Use several sheets if necessary)

Docket Number: 00026.05CON

Application Number: 10/766,566

Applicant: Joshua D. RABINOWITZ et al.

Filing Date: 1/27/2004

Group Art Unit: Not Yet Known

113.

8/12/2004

US 2004/0156790

Rabinowitz et al.

114.

08/12/2004

US 2004/0156791

Rabinowitz et al.

FOREIGN PATENT DOCUMENTS

Examiner
Initials

Ref.
No.

Date

Document No.

Country

Class

Subclass

Translation
YES NO

115.

03/14/1990

EP0 358 114

Europe

116.

07/03/2001

EP 1 080 720

Europe

117.

08/29/2001

EP 0 606 486

Europe

118.

06/13/1991

WO 91/07947

WO

119.

04/11/1996

WO 96/09846

WO

120.

05/09/1996

WO 96/13161

WO

("K/OQ/1 QQf>
UJ/V7/ 1 yyv

WD 96/1 3290
vv kj y\jf kj4>y\j

WO

122.

05/09/1996

WO 96/13291

WO

123.

05/09/1996

WO 96/13292

WO

124.

10/03/1996

WO 96/30068

WO

125.

11/28/1996

WO 96/37198

WO

126.

08/07/1997

WO 97/27804

wrpo

127.

05/28/1998

WO 98/22170

WO

128.

07/23/1998

WO 98/31346

wo

129.

08/27/1998

WO 98/36651

wo

130.

04/08/1999

WO 99/16419

wo

131.

12/16/1999

WO 99/64094

wo

132.

01/06/2000

WO 00/00176

wo

133.

01/06/2000

WO 00/00215

wo

134.

05/18/2000

WO 00/27363

wo

135.

05/25/2000

WO 00/29053

wo

136.

09/17/2000

WO 00/47203

wo

EXAMEN

ER:

. DATE CONSIDERED:

EXAMINER: Initial if citation considered, whether or not the citation conforms with MPEP 609. Draw a line through the citation if not in
conformance and not considered. Include a copy of this form with next communication to applicant.

PTO/SB/08 (2-92)

Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE

PTO/SB/08 (2-92)
Sheet 6 of 8

Form PTO- 1449

INFORMATION DISCLOSURE CITATION
IN AN APPLICATION

(Use several sheets if necessary)

Docket Number: 00026.05CON

Application Number: 10/766,566

Applicant: Joshua D. RABINOWITZ et al.

Filing Date: 1/27/2004

Group Art Unit: Not Yet Known

137.

1 1/02/2000

WO 00/64940

WIPO

138.

11/09/2000

WO 00/66084

WO

139.

11/09/2000

WO 00/66206

WIPO

140.

12/21/2000

WO 00/76673

wo

141.

01/25/2001

WO 01/05459

wo

142.

03/01/2001

WO 01/13957

wo

143.

03/15/2001

WO 01/17568

wo

144.

06/14/2001

WO 01/41732

wo

145.

12/20/2001

WO 01/95903

wo

146.

03/28/2002

WO 02/24158

wo

147.

03/28/2002

WO 02/24158

wo

EXAMINER:

DATE CONSIDERED:

EXAMINER: Initial if citation considered, whether or not the citation conforms with MPEP 609. Draw a line through the citation if not in
conformance and not considered. Include a copy of this form with next communication to applicant.

PTO/SB/ 08 (2-92) Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE

PTO/SB/08 (2-92)
Sheet 7 of 8

FormPTO-1449

TKTTA'nA K A TTAXT TMPOT ACT TT> T? ATT A TTAXT

INFORMATION DISCLOSURE CITATION
IN AN APPLICATION

(Use several sheets if necessary)

Docket Number: 00026.05CON

Application Number: 10/766,566

Applicant: Joshua D. RABINOWITZ et al.

Filing Date: 1/27/2004

Group Art Unit: Not Yet Known

OTHER DOCUMENTS

(including author, title, Date, Pertinent Pages, Etc.)

Examiner
Initials

Ref.
No.

Title

148.

Bennett, R.L. et al. (1981). "Patient-Controlled Analgesia: A New Concept of Postoperative Pain
Relief," Annual Surg; 195(6):700-705.

149.

Carroll, M.E. et al. (1990), "Cocaine-base smoking in rhesus monkeys: reinforcing and physiological
effects," Psychopharmacology (Berl). 102:443-450.

150.

Clark, A. and Byron, P. (1986). "Dependence of Pulmonary Absorption Kinetics on Aerosol Particle
Size " Z Erkrank. 166:13-24.

151.

Darquenne, C et al. (1997). "Aerosol Dispersion in Human Lung: Comparison Between Numerical
Simulations and Experiments for Bolus Tests," American Physiological Society. 966-974.

152.

Davies, C.N. et al. (May 1972). "Breathing of Half-Micron Aerosols," Journal of Applied Physiology.
32(5):591-600.

153.

Dershwitz, M., M.D., et al. (September 2000). "Pharmacokinetics and Pharmacodynamics of Inhaled
versus Intravenous Morphine in Healthy Volunteers," Anesthesiology. 93(3): 619-628.

154.

Finlay, W.H. (2001). "The Mechanics of Inhaled Pharmaceutical Aerosols", Academic Press: San
Diego Formula 2.39. pp.3-14 (Table of Contents), pp. v-viii.

155.

Gonda,I. (1991). "Particle Deposition in the Human Respiratory Tract," Chapter 176, The Lung:
Scientific Foundations . Crystal R.G. and West, J.B. (eds.), Raven Publishers, New York. pp. 2289-
2294.

156.

Hatsukami D, et al. (May 1990) "A method for delivery of precise doses of smoked cocaine-base to
humans." Pharmacology Biochemistry & Behavior. 36(1): 1-7.

Heyder, J. et al. (1986). "Deposition of Particles in the Human Respiratory Tract in the Size Range
0.005-15 /im,"y. Aerosol Sci. 17(5):81 1-822.

157.

158.

Huizer, H., "Analytical studies on illicit heron. V. Efficacy of volatilization during heroin smoking.'
Pharmaceutisch Weekblad Scientific Edition (1987). 9(4):203-21 1 .

159.

Hurt, R.D., MD and Robertson, C.R., PhD, (October 1998). "Prying Open the Door to the Tobacco
Industry's Secrets About Nicotine: The Minnesota Tobacco Trial," JAMA 280(13):1 173-1 181.

160.

Lichtman, A.H. et al. (1996). "Inhalation Exposure to Volatilized Opioids Produces Antinociception
in Mice," Journal of Pharmacology and Experimental Therapeutics. 279(l):69-76.

161.

Martin, B.R. and Lue, L.P. (May/June 1989). "Pyrolysis and Volatilization of Cocaine," Journal of
Analytical Toxicology 13:158-162.

162.

Mattox, A.J. and Carroll, M.E., (1996).
Psychopharmacology, 125:195-201.

'Smoked heroin self-administration in rhesus monkeys,"

EXAMINER:

DATE CONSIDERED:

EXAMINER: Initial if citation considered, whether or not the citation conforms with MPEP 609. Draw a line through the citation if not in
conformance and not considered. Include a copy of this form with next communication to applicant.

PTO/SB/ 08 (2-92)

Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE

PTO/SB/08 (2-92)
Sheet 8 of 8

FormPTO-1449

INFORMATION DISCLOSURE CITATION
IN AN APPLICATION

(Use several sheets if necessary)

Docket Number: 00026.05CON

Application Number: 10/766,566

Applicant: Joshua D. RABINOWITZ et al.

Filing Date: 1/27/2004

Group Art Unit: Not Yet Known

163.

Meng, Y. et al. "Inhalation Studies With Drugs of Abuse, " NIDA Research Monograph, (1 997)
173:201-224.

164.

Meng, Y., et al. (1999). "Pharmacological effects of methamphetamine and other stimulants via
inhalation exposure," Drug and Alcohol Dependence. 53 : 1 1 1 -120.

165.

Office Action mailed 8/13/2003 tor US application 10/153,313 riled 05/zl/zOOz UiiJJLviiK i ur
BENZODIAZEPINES THROUGH AN INHALATION ROUTE"

166.

Pankow, J.F. et al. (1997). "Conversion of Nicotine in Tobacco Smoke to Its Volatile and Available
Free-Base Form Through the Action of Gaseous Ammonia, Envron. Scu lecnnoL 31:2428-2433.

167.

Pankow, J. (March 2000). ACS Conference-San Francisco-3/26/00. Chemistry of Tobacco Smoke,
pp. 1-8.

168.

Seeman, J. et al. (1999). "The Form of Nicotine in Tobacco. Thermal Transfer of Nicotine and
Nicotine Acid Salts to Nicotine in the Gas Phase, "J. Agric. Food Chem. 47(12):5 133-5 145.

169.

Sekine, H. and Nakahara, Y. (1987). "Abuse of Smoking Methamphetamine Mixed with Tobacco: 1.
Inhalation Efficiency and Pyrolysis Products of Methamphetamine," Journal of Forensic Science
32(5):1271-1280.

170.

Vapotronics. Inc. (T998) located at http://www.vapotronics.com.au/banner.htm., 1 1 pages, (visited on
June 5, 2000).

171.

Ward, M.E. MD, et al. (December 1997). "Morphine Pharmacokinetics after Pulmonary
Administration from a Novel Aerosol Delivery System," Clinical Pharmacology & Therapeutics
62(6):596-609.

172.

Wood, R.W. et al. (1996). "Generation of Stable Test Atmospheres of Cocaine Base and Its
Pyrolyzate, Methylecgonidine, and Demonstration of Their Biological Activity." Pharmacology
Biochemistry & Behavior. 55(2):237-248.

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PTO/SB/08 (2-92)

Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE